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Anti-G-quadruplex, Recombinant [BG4]

Invented by Shankar Balasubramanian, John McCafferty, David Tannahill, Giulia Biffi

Info

Applications ELISA IF ChIP-seq
Antigen/Gene or Protein Targets DNA/RNA G-quadruplex structures in human cells
Reactivity Human
Relevance BG4 is an engineered, structure-specific antibody probe that binds with high selectivity and low nanomolar affinity to DNA G-quadruplex structures can can be employed to visualize DNA G-quadruplex structures in the genomic DNA of human cells.
BG4 has high affinity for intramolecular and intermolecular DNA G-quadruplexes (Kd 0.5 – 1.6 nM, and 2.0 nM respectively) with no detectable binding to a RNA hairpin, single-stranded or double-stranded DNA.
Immunogen BG4, a single-chain antibody, was isolated from the Sanger phage display library through selection using a panel of intramolecular G-quadruplex structures.
Research Area Epigenetics & Nuclear Signalling

References: 8 entries

Biffi et al. 2013. Nat Chem. 5(3):182-6. PMID: 23422559.

IF ELISA

Biffi et al. 2014. Nat Chem. 6(1):75-80. PMID: 24345950.

IF

Yangyuoru et al. 2015. Angew Chem Weinheim Bergstr Ger. 127(3):924-927. PMID: 26300569.

Hänsel-Hertsch et al. 2016. Nat Genet. :. PMID: 27618450.

ChIP-seq

G-quadruplex structures mark human regulatory chromatin.

Europe PMC ID: 27618450

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

Europe PMC ID: 26300569

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

Europe PMC ID: 24345950

Quantitative visualization of DNA G-quadruplex structures in human cells.

Europe PMC ID: 23422559


Add a reference

References: 8 entries

Biffi et al. 2013. Nat Chem. 5(3):182-6. PMID: 23422559.

IF ELISA

Biffi et al. 2014. Nat Chem. 6(1):75-80. PMID: 24345950.

IF

Yangyuoru et al. 2015. Angew Chem Weinheim Bergstr Ger. 127(3):924-927. PMID: 26300569.

Hänsel-Hertsch et al. 2016. Nat Genet. :. PMID: 27618450.

ChIP-seq

G-quadruplex structures mark human regulatory chromatin.

Europe PMC ID: 27618450

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

Europe PMC ID: 26300569

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

Europe PMC ID: 24345950

Quantitative visualization of DNA G-quadruplex structures in human cells.

Europe PMC ID: 23422559


Add a reference

References: 8 entries

Biffi et al. 2013. Nat Chem. 5(3):182-6. PMID: 23422559.

IF ELISA

Biffi et al. 2014. Nat Chem. 6(1):75-80. PMID: 24345950.

IF

Yangyuoru et al. 2015. Angew Chem Weinheim Bergstr Ger. 127(3):924-927. PMID: 26300569.

Hänsel-Hertsch et al. 2016. Nat Genet. :. PMID: 27618450.

ChIP-seq

G-quadruplex structures mark human regulatory chromatin.

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

Quantitative visualization of DNA G-quadruplex structures in human cells.


Add a reference


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