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Anti-Nitrosylated Amyloid-ß (Tyr10) [4A5E8]

Info

Applications ELISA IHC IP WB
Antigen/Gene or Protein Targets Amyloid-ß
Reactivity Human
Relevance Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes to cell signaling by inducing posttranslational protein modifications. Under pathological conditions there is a shift from the signal transducing actions to the formation of protein tyrosine nitration by secondary products like peroxynitrite and nitrogen dioxide. Amyloid β (Aβ) has been identified as an NO target, which is nitrated at tyrosine 10 (3NTyr10-Aβ). Nitration of Aβ accelerated its aggregation and was detected in the core of Aβ plaques of APP/PS1 mice and AD brains.
Host Mouse
Immunogen Nitration-site in Amyloid-ß nitrated at Tyrosine 10.
Research Area Neurobiology

References: 1 entry

Kummer et al. 2011. Neuron. 71(5):833-44. PMID: 21903077.


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References: 1 entry

Kummer et al. 2011. Neuron. 71(5):833-44. PMID: 21903077.


Add a reference

References: 1 entry

Kummer et al. 2011. Neuron. 71(5):833-44. PMID: 21903077.


Add a reference


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