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Anti-Histone H3 [1B1-B2]

Invented by Egon Ogris at Medical University Of Vienna

Info

Applications ChIP WB
Antigen/Gene or Protein Targets Human histone H3
Reactivity Human, Mouse, Saccharomyces, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Saccharomyces frugiperda
Relevance Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified, and histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation.
Host Mouse
Immunogen Linear peptide corresponding to the C-terminus of human histone H3.
Subclass IgG
Research Area Cell Structure and Motility, Epigenetics & Nuclear Signalling

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