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Anti-hEMILIN2 [hEMIL2] monoclonal antibody
Invented by Professor Alfonso Colombatti at National Cancer Institute CRO - Aviano
Anti-hEMILIN1 [hEMIL1] monoclonal antibody
Invented by Professor Alfonso Colombatti , Dr Maurizio Mongiat from National Cancer Institute CRO - Aviano , Dr Paola Spessotto , Dr Roberto Doliana , Maria Teresa Mucignat
Invented at National Cancer Institute CRO - Aviano
- Datasheet
- References (11)
- Inventor Info
Info
| Catalogue Number | 160586 |
| Applications | ELISA IHC IF IP Fn WB |
| Antigen/Gene or Protein Targets | hEMILIN1 |
| Reactivity | Human |
| Relevance | Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the α4β1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFβ preventing its maturation to mature TGFβ in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance. |
| Host | Mouse |
| Immunogen | Recombinant human Emilin-1 as immunizing antigen; Balb/c mice as host |
| Positive Control | IgG2a kappa |
| Notes |
Storage Conditions Store at 2-8°C or aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
| Research Area | Cancer |
Anti-mMMRN2 [mMMRN2] monoclonal antibody
Invented by Professor Alfonso Colombatti at National Cancer Institute CRO - Aviano
Anti-mEMILIN1 [mEMIL] monoclonal antibody
Invented by Professor Alfonso Colombatti at National Cancer Institute CRO - Aviano
References: 11 entries
Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
Pivetta et al. 2014. Matrix Biol. 34:22-32. PMID: 24513040.
Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
Spessotto et al. 2006. J Cell Sci. 119(Pt 21):4574-84. PMID: 17074837.
Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.
Zanetti et al. 2004. Mol Cell Biol. 24(2):638-50. PMID: 14701737.
Spessotto et al. 2003. J Biol Chem. 278(8):6160-7. PMID: 12456677.
Doliana et al. 1999. J Biol Chem. 274(24):16773-81. PMID: 10358019.
Add a reference
References: 11 entries
Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
Pivetta et al. 2014. Matrix Biol. 34:22-32. PMID: 24513040.
Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
Spessotto et al. 2006. J Cell Sci. 119(Pt 21):4574-84. PMID: 17074837.
Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.
Zanetti et al. 2004. Mol Cell Biol. 24(2):638-50. PMID: 14701737.
Spessotto et al. 2003. J Biol Chem. 278(8):6160-7. PMID: 12456677.
Doliana et al. 1999. J Biol Chem. 274(24):16773-81. PMID: 10358019.
Add a reference
Inventor Information
Inventors
|
Professor Alfonso Colombatti |
|
|
Dr Maurizio Mongiat |
|
from National Cancer Institute CRO - Aviano |
|
|
Dr Paola Spessotto |
|
|
Dr Roberto Doliana |
|
|
Maria Teresa Mucignat |
