Cancer Research Technology
Log in Register
Menu

Anti-mEMILIN1 [mEMIL] monoclonal antibody

Invented by Professor Alfonso Colombatti , Dr Roberto Doliana , Dr Paola Spessotto , Maria Teresa Mucignat
Invented at National Cancer Institute CRO - Aviano

Info

Catalogue Number 160584
Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets mEMILIN1
Reactivity Mouse
Relevance Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the α4β1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
Host Rat
Immunogen Recombinant murine Emilin-1 as immunizing antigen; Wistar rat as host
Positive Control IgG2a kappa
Notes Storage Conditions
Store at 2-8°C or aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Concentration
Western Blot use at 2-10 μg/ml
Research Area Cancer

References

There are 7 reference entries for this reagent.

View All References

References: 7 entries

Pivetta et al. 2016. Clin Sci (Lond). 130(14):1221-36. PMID: 26920215.

Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.

Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.

Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.

Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.

Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.

Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.


Add a reference

References: 7 entries

Pivetta et al. 2016. Clin Sci (Lond). 130(14):1221-36. PMID: 26920215.

Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.

Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.

Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.

Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.

Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.

Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.


Add a reference

Inventor Information

Inventors

Professor Alfonso Colombatti

Professor Alfonso Colombatti

Dr Roberto Doliana

Dr Roberto Doliana

Dr Paola Spessotto

Dr Paola Spessotto

Maria Teresa Mucignat

Maria Teresa Mucignat

Add an inventor