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CXCR3-GFP knock-in mouse
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Invented by Abhay Satoskar at Ohio State University

Info

Catalogue Number 157948
Antigen/Gene or Protein Targets CXCR3
Disease Keywords allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth
Model Knock-In
Relevance Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis. CXC chemokine receptor 3 (CXCR3) is expressed by natural killer cells, neutrophils, T cells and plasmacytoid dendritic cells. CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases. There is a significant need for animal models to track and investigate CXCR3 expressing cells for diagnostic and therapeutic tool development.
Research Area Cancer, Immunology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.

Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.


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References: 2 entries

Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.

Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.


Add a reference

Inventor Information