Cancer Research Technology
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Catalogue Number 153787
Backbone Size (bp) 3461
Bacterial Resistance Ampicillin
Vector Type pQE30
Synonyms TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
Antigen/Gene or Protein Targets TDP43 N-terminal domain 1-102
Relevance The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The N-terminal region of TDP-43 is a highly structured sequence that contributes to the reversible dimerization and oligomerization of this protein. It contains a bipartite Nuclear Localization Signal that ensures the predominant nuclear localization of TDP-43.
Research Area Gene Expression, Neurobiology, Virology
Notes Concentration 1.2mg/ml

References

There are 2 reference entries for this reagent.

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References: 2 entries
RECENTLY UPDATED

Mompeán et al. 2016. FEBS J. 283(7):1242-60. PMID: 26756435.

The TDP-43 N-terminal domain structure at high resolution.

Europe PMC ID: 26756435


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References: 2 entries
RECENTLY UPDATED

Mompeán et al. 2016. FEBS J. 283(7):1242-60. PMID: 26756435.

The TDP-43 N-terminal domain structure at high resolution.


Add a reference