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Anti-TCR Cβ1, Recombinant [JOVI.1]

Info

Catalogue Number 153363
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets TCR Cβ1
Reactivity Human
Relevance Recombinant antibody which aids investigation into T-cell mediated diseases.

Background and Research Application
The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR’s recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor β locus have been associated with T cell lymphomas.

Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI·1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different Vβ regions.
Host Mouse
Subclass IgG2a
Formulation PBS
Concentration 1mg/ml
Research Area Cell Type or Organelle Marker, Immunology
Immunogen UniProt ID P01850
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
JOVI.1 monoclonal antibody that targets TCRBC1+ cells in a selective manner by recognizing 2 amino acid residues specifically exposed in TCRBC1 but not in TCRBC2.

Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

Concentration
1mg/ml as standard

References

There are 1 reference entries for this reagent.

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References: 1 entry

Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.


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References: 1 entry

Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.


Add a reference