Anti-TCR Cβ1 [JOVI.1]
Invented by Dr Mike Owen at Cancer Research UK London Research Institute: Lincoln's Inn Fields
Anti-TCR Cβ1, Recombinant [JOVI.1]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153363 |
| Applications | FACS IHC IF IP |
| Antigen/Gene or Protein Targets | TCR Cβ1 |
| Reactivity | Human |
| Relevance |
Recombinant antibody which aids investigation into T-cell mediated diseases. Background and Research Application The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR’s recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor β locus have been associated with T cell lymphomas. Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI·1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different Vβ regions. |
| Host | Mouse |
| Subclass | IgG2a |
| Formulation | PBS |
| Concentration | 1mg/ml |
| Research Area | Cell Type or Organelle Marker, Immunology |
| Immunogen UniProt ID | P01850 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest JOVI.1 monoclonal antibody that targets TCRBC1+ cells in a selective manner by recognizing 2 amino acid residues specifically exposed in TCRBC1 but not in TCRBC2. Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Concentration 1mg/ml as standard |
References: 1 entry
Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.
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References: 1 entry
Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.
Add a reference
