Anti-TCR CBeta1 [JOVI.1]rAb

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-TCR CBeta1 [JOVI.1]rAb
• Clone: rJOVI.1
• Tool sub type: Primary antibody
• Class: Recombinant
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; IF ; IP
• Description: Recombinant antibody which aids investigation into T-cell mediated diseases. Background and Research Application The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR’s recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor ? locus have been associated with T cell lymphomas. Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI?1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V? regions.
• Immunogen: Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.
• Immunogen uniprot id: P01850
• Isotype: IgG2a

Target Details

• Target: TCR C?1
• Target background: Recombinant antibody which aids investigation into T-cell mediated diseases. Background and Research Application The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor ? locus have been associated with T cell lymphomas. Recombinant version of the anti-JOVI.1 monoclonal antibody. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V? regions.

Applications

• Application: FACS ; IHC ; IF ; IP

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS
• Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
• Shipping conditions: Shipping at 4° C

Related Tools

• Related tools: Anti-TCR C?1 [JOVI.1]

References

• Original hybridoma first published in: Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.