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Gfi1P2A/P2A Mouse

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Model Knock-In
Relevance The Snail/Gfi1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors. Gfi1 is expressed in the hematopoietic and nervous system. Consequently, mutations of Gfi1 cause defects in hematopoiesis and inner ear development. In the Gfi1P2A/P2A mouse strain, a point mutation has been inserted in the SNAG domain that replaces a proline at amino acid position 2 by alanine (P2A). This completely abrogates the activity of Gfi1 as transcriptional repressor.
Conditional No
Research Area Stem Cell Biology
Notes Gfi1 and its paralogue Gfi1b have overlapping, however differential functions in hematopoiesis. Loss of Gfi1 in mice affects pre-T-cell differentiation, the development of neutrophil granulocytes and inner ear hair cells, whereas in contrast loss of Gfi1b impairs the development of erythroid cells and megacaryocytes. Therefore, Gfi1P2A/P2A mice can be used as a model to study and treat deafness as a consequence of defects of inner ear development as well as defects of hematopoiesis in immunological disorders.

References

There are 8 reference entries for this reagent.

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References: 8 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Europe PMC ID: 16397623

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

Europe PMC ID: 15618011

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

Europe PMC ID: 12441305

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.

Europe PMC ID: 11825872


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References: 8 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.


Add a reference

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