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Anti-CREB1, Polyclonal [CREB1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets CREB1
Reactivity Human and Mouse
Relevance This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser­133 phosphorylation. Implicated in synchronization of circadian rhythmicity. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP­responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]  
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 36.7 [Isoform CREB­A], 35.1 [Isoform CREB­]
Research Area Epigenetics & Nuclear Signalling, Immunology

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