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Anti-EPAS1, Polyclonal [EPAS1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets EPAS1
Reactivity Human and Mouse
Relevance Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'­[AG]CGTG­3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie­2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 96.4  
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

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