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A2780 Cell Line

Info

Catalogue Number 152706
Host Human
Tissue Ovary
Disease Keywords Ovarian cancer cell line
Model Tumour line
Relevance The A2780 human ovarian cancer cell line was established from tumour tissue from an untreated patient. Cells grow as a monolayer and in suspension in spinner cultures. A2780 is the parent line to the cisplatin resistant cell line A2780 cis (catalogue no. 152708) and the adriamycin resistant cell line A2780 ADR (catalogue no. 152707).
Production Details Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 3-6x10,000cells/cm² using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C.
Conditional No
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
Notes STR-PCR Data:
Amelogenin: X
CSF1PO: 10,11
D13S317: 12,13
D16S539: 11,13
D5S818: 11,12
D7S820: 10
THO1: 6
TPOX: 8,10
vWA: 15,16
Cellosaurus ID CVCL_0134

References

There are 12 reference entries for this reagent.

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References: 12 entries

Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.

Europe PMC ID: 24804215

Januchowski et al. 2014. Biomed Res Int. 2014:365867. PMID: 24804215.

Han et al. 2013. Oncol Lett. 6(5):1295-1298. PMID: 24179511.

A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties.

Europe PMC ID: 24179511

Barretina et al. 2012. Nature. 483(7391):603-7. PMID: 22460905.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Europe PMC ID: 22460905

Yu et al. 2000. Int J Oncol. 16(3):555-60. PMID: 10675489.

Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene.

Europe PMC ID: 10675489

Henkels et al. 1997. Cancer Res. 57(20):4488-92. PMID: 9377558.

Induction of apoptosis in cisplatin-sensitive and -resistant human ovarian cancer cell lines.

Europe PMC ID: 9377558

Parker et al. 1991. J Clin Invest. 87(3):772-7. PMID: 1999494.

Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.

Europe PMC ID: 1999494


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References: 12 entries

Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.

Januchowski et al. 2014. Biomed Res Int. 2014:365867. PMID: 24804215.

Han et al. 2013. Oncol Lett. 6(5):1295-1298. PMID: 24179511.

A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties.

Barretina et al. 2012. Nature. 483(7391):603-7. PMID: 22460905.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Yu et al. 2000. Int J Oncol. 16(3):555-60. PMID: 10675489.

Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene.

Henkels et al. 1997. Cancer Res. 57(20):4488-92. PMID: 9377558.

Induction of apoptosis in cisplatin-sensitive and -resistant human ovarian cancer cell lines.

Parker et al. 1991. J Clin Invest. 87(3):772-7. PMID: 1999494.

Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.


Add a reference

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