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Anti-Notch-1 [22E5.5]

Info

Applications FACS IP
Antigen/Gene or Protein Targets Notch-1
Synonyms Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); AOVD1; AOS5
Reactivity N/A
Relevance Notch1, also known as neurogenic locus notch homolog protein 1, is a large >270 kD protein that functions as a receptor for the membrane ligands Jagged1, Jagged2 and Delta1 to regulate cell fate decisions. Upon ligand activation, the transmembrane Notch1 receptor is cleaved by TNF-alpha converting enzyme (TACE) to produce a membrane-associated intermediate fragment (NEXT). This fragment is further cleaved by presenilin-dependent gamma secretase to release a notch-derived peptide containing the intracellular fragment from the membrane. The released Notch intracellular fragment (NICD) translocates to the nucleus and forms a transcriptional complex with the RBP-J κ transcriptional activator complex to alter differentiation, proliferation, and apoptotic programs. Notch 1 is highly expressed in the brain, lung, and thymus (CD4-CD8-cells and CD4-CD8+ cells) with lower levels of expression observed in the spleen, bone marrow, spinal cord, eyes, mammary gland, liver, intestine, kidney and heart.
Host Rat
Research Area Cardiovascular, Developmental Biology, Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology

References

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References: 1 entry

Fiorini et al. 2009. J Immunol. 183(11):7212-22. PMID: 19915064.


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References: 1 entry

Fiorini et al. 2009. J Immunol. 183(11):7212-22. PMID: 19915064.


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