Anti-POLR2A [1PB-7E11]

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Info

Applications	ELISA IF WB
Antigen/Gene or Protein Targets	RNA Polymerase B Subunit hRPB1
Reactivity	Human
Relevance	POLR2A is the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Host	Mouse
Immunogen	Synthetic peptide (TSPSYSPTSPSYSPTSPSYSP) coupled to ovalbumin.
Subclass	IgG1 kappa
Notes	Available in 100ul unit as ascites.
Research Area	Epigenetics & Nuclear Signalling

Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.

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Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.

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Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.

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