Anti-POLR2A [1PB-7E11]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | RNA Polymerase B Subunit hRPB1 |
| Reactivity | Human |
| Relevance | POLR2A is the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. |
| Host | Mouse |
| Immunogen | Synthetic peptide (TSPSYSPTSPSYSPTSPSYSP) coupled to ovalbumin. |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit as ascites. |
| Research Area | Epigenetics & Nuclear Signalling |
References: 2 entries
Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.
Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2).
Europe PMC ID: 10536148
Add a reference
References: 2 entries
Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.
Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2).
Europe PMC ID: 10536148
Add a reference
References: 2 entries
Bonnet et al. 1999. Nucleic Acids Res. 27(22):4399-404. PMID: 10536148.
Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2).
Add a reference
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