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Anti-HDAC3 [3G6]

Invented by Egon Ogris at Medical University Of Vienna

Info

Applications IP WB
Antigen/Gene or Protein Targets HDAC3
Reactivity Bovine, Hamster, Human and Mouse
Relevance Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene.
Host Mouse
Immunogen peptide corresponding to human HDAC3
Subclass IgG2a
Molecular Weight (kDa) 50
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

References: 4 entries

Gupta et al. 2009. PLoS One. 4(2):e4363. PMID: 19204783.

Thiagalingam et al. 2003. Ann N Y Acad Sci. 983:84-100. PMID: 12724214.

Fischle et al. 2002. Mol Cell. 9(1):45-57. PMID: 11804585.

Emiliani et al. 1998. Proc Natl Acad Sci U S A. 95(6):2795-800. PMID: 9501169.


Add a reference

References: 4 entries

Gupta et al. 2009. PLoS One. 4(2):e4363. PMID: 19204783.

Thiagalingam et al. 2003. Ann N Y Acad Sci. 983:84-100. PMID: 12724214.

Fischle et al. 2002. Mol Cell. 9(1):45-57. PMID: 11804585.

Emiliani et al. 1998. Proc Natl Acad Sci U S A. 95(6):2795-800. PMID: 9501169.


Add a reference

References: 4 entries

Gupta et al. 2009. PLoS One. 4(2):e4363. PMID: 19204783.

Thiagalingam et al. 2003. Ann N Y Acad Sci. 983:84-100. PMID: 12724214.

Fischle et al. 2002. Mol Cell. 9(1):45-57. PMID: 11804585.

Emiliani et al. 1998. Proc Natl Acad Sci U S A. 95(6):2795-800. PMID: 9501169.


Add a reference


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