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Anti-LIMD1 [3F2/G6]


Catalogue Number 151611
Applications ELISA IHC IF IP WB
Antigen/Gene or Protein Targets LIM domains-containing protein 1 (LIMD1)
Reactivity Human
Relevance LIMD1 (LIM domain-containing protein 1) is part of the zyxin/ajuba family of proteins and is a ubiquitously expressed tumour suppressor containing three LIM zinc-binding domains. LIMD1 may be involved in cell anchoring via focal adhesions and in the cell cycle, particularly during mitosis. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers, and it has since been noted to be downregulated in lung and breast cancers.
Host Mouse
Immunogen Recombinant LIMD1
Subclass IgG1
Positive Control H1299 cell lysate
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Epigenetics & Nuclear Signalling

References: 3 entries

Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.

Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.

Sharp et al. 2004. Proc Natl Acad Sci U S A. 101(47):16531-6. PMID: 15542589.

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