Anti-LIMD1 [3F2/G6]
Invented by Dr Tyson Sharp at Barts Cancer Institute
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| Catalogue Number | 151611 |
| Applications | ELISA IHC IF IP WB |
| Antigen/Gene or Protein Targets | LIM domains-containing protein 1 (LIMD1) |
| Reactivity | Human |
| Relevance | LIMD1 (LIM domain-containing protein 1) is part of the zyxin/ajuba family of proteins and is a ubiquitously expressed tumour suppressor containing three LIM zinc-binding domains. LIMD1 may be involved in cell anchoring via focal adhesions and in the cell cycle, particularly during mitosis. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers, and it has since been noted to be downregulated in lung and breast cancers. |
| Host | Mouse |
| Immunogen | Recombinant LIMD1 |
| Subclass | IgG1 |
| Positive Control | H1299 cell lysate |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Epigenetics & Nuclear Signalling |
References: 6 entries
Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Europe PMC ID: 22286099
Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Europe PMC ID: 19060205
Sharp et al. 2004. Proc Natl Acad Sci U S A. 101(47):16531-6. PMID: 15542589.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
Europe PMC ID: 15542589
Add a reference
References: 6 entries
Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Europe PMC ID: 22286099
Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Europe PMC ID: 19060205
Sharp et al. 2004. Proc Natl Acad Sci U S A. 101(47):16531-6. PMID: 15542589.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
Europe PMC ID: 15542589
Add a reference
References: 6 entries
Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Sharp et al. 2004. Proc Natl Acad Sci U S A. 101(47):16531-6. PMID: 15542589.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
Add a reference
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