Anti-XPG [8H7/XPG]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (10)
- Inventor Info
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| Catalogue Number | 151063 |
| Applications | ELISA FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | XPG |
| Reactivity | Human |
| Relevance | XPG is a DNA endonuclease that is essential for the dual incision step of nucleotide excision repair (cleaves 3' of the DNA lesion). XPG might be involved in the DNA replication and repair deficiency syndromes Cockayne Syndrome and Xeroderma pigmentosa. |
| Host | Mouse |
| Immunogen | Recombinant human XPG protein produced in baculovirus |
| Positive Control | LnCap cells |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 185 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | 8H7/XPG stains XPG in the nuclei of human cells. |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 10 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
Europe PMC ID: 23209410
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
Igoucheva et al. 2006. Oligonucleotides. 16(1):94-104. PMID: 16584298.
Bomgarden et al. 2006. EMBO J. 25(11):2605-14. PMID: 16675950.
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.
Europe PMC ID: 16675950
Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification.
Europe PMC ID: 16584298
Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.
Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
Europe PMC ID: 11259578
Evans et al. 1997. EMBO J. 16(3):625-38. PMID: 9034344.
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein.
Europe PMC ID: 9034344
Add a reference
References: 10 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
Igoucheva et al. 2006. Oligonucleotides. 16(1):94-104. PMID: 16584298.
Bomgarden et al. 2006. EMBO J. 25(11):2605-14. PMID: 16675950.
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.
Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification.
Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.
Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
Evans et al. 1997. EMBO J. 16(3):625-38. PMID: 9034344.
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein.
Add a reference
