Cancer Research Technology
Log in Register
Menu

UM-UC-1 (Human bladder transitional cell carcinoma) cell line

Invented at University Of Michigan

Info

Catalogue Number 160436
Synonyms UM-UC-1
Host Human
Tissue Lymphatic Tissue
Disease Keywords Human bladder translational cell carcinoma
Model Cancer Model
Relevance UM-UC-1 are a human transitional cell carcinoma originating from lymphatic metastasis of transitional cell carcinoma of the bladder of a 26-year old black male.

These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish common observed phenomena across cells of the same type of neoplasm.

Tumorigenicity studies in nude mice revealed the UM-UC-1 produced tumors, 1-1.5 cm in diameter in < 3 weeks. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-1 did, however, have one of the highest levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested.
Research Area Cancer
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37C in 5% CO2 environment.

References

There are 2 reference entries for this reagent.

View All References

References: 2 entries

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.


Add a reference

References: 2 entries

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor