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UM-UC-10 (Human transitional cell carcinoma of the bladder) cell line

Invented at University Of Michigan

Info

Catalogue Number 160440
Synonyms UM-UC-10
Host Human
Tissue Bladder
Disease Keywords Human bladder transitional cell carcinoma
Model Cancer Model
Relevance UM-UC-10 are a human transitional cell carcinoma of the bladder.

These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-10 do not produce tumors, even after extended observation. UM-UC-10 were more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-10 also showed low levels of Coxsackie adenovirus receptor (CAR) expression.

These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm.
Research Area Cancer
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37C in 5% CO2 environment.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.


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References: 2 entries

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.


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