| Catalogue Number | 158320 |
| Amino Acid Sequence | PPRRGLIKLKTS |
| Cellular/Tissue Localisation | Extracellular matrix |
| Synonyms | PL1, FN-EDB and TNC-C binding protein |
| Relevance | PL1 peptide is a short binding peptide which interacts with oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C) which are both extracellular matrix proteins present in a tumour microenvironment. The targets of PL1 are nearly absent in normal adult tissues making them indicative of solid tumour tissues. It has been shown that this dual-targeted peptide can be used for robust and specific delivery of imaging agents and therapeutic payloads to solid tumours. |
| Antigen/Gene or Protein Targets | Oncofetal fibronectin extra domain-B (FN-EDB) and tenascin-C C domain (TNC-C). Relevant disease: Cancer |
| Research Area | Cancer, Extracellular Matrix |
Invented by Prakash Lingasamy at University of Tartu
Invented by Prakash Lingasamy at University of Tartu
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Tambet Teesalu |
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Prakash Lingasamy |
