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Peptides and Proteins

PL2 Peptide

Invented by Prakash Lingasamy , Tambet Teesalu
Invented at University of Tartu
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Catalogue Number 157665
Amino Acid Sequence TSKQNSR
Cellular/Tissue Localisation PL2 is specific to oncofetal fibronection Extra Domain-B
Synonyms PL2, Oncofetal fibronectin (FN-EDB) specific peptide
Relevance Oncofetal fibronectin (FN-EDB) is not present in the extracellular matrix of adult tissues but it is up-regulated in tumours and malignant tissues. It has previously been used as a target for antibody-based therapies. The PL2 specific peptide has enhanced affinity to bind to FN-EDB so may be useful as an affinity ligand for delivery of diagnostic compounds into solid tumours.
Antigen/Gene or Protein Targets Oncofetal fibronectin (FN-EDB)
Research Area Cancer, Extracellular Matrix

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Inventor Information

Inventors

Prakash Lingasamy

Prakash Lingasamy

Tambet Teesalu

Tambet Teesalu

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Invented at

University of Tartu
University of Tartu

27 reagents listed on Ximbio