Fluorescent probe for Copper
Invented by Christoph J. Fahrni
Invented at Georgia Institute Of Technology
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- References (2)
- Inventor Info
Info
| Catalogue Number | 153939 |
| Antigen/Gene or Protein Targets | Copper I; Cu(I) |
| Type | Fluorescent Probe |
| Relevance | Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. Here, Dr. Farhrni has designed a water-solube fluorescence probe for the detection of aqueous Cu(I). This probe has a high selectivity (57-fold) for Cu(I) compared to other cations such as Cu(II), Hg(II), and Cd(II). |
| In vitro applications | determination of Cu(I) binding affinities of proteins and small-molecule ligands |
| Solubility | water |
| Research Area | Drug Discovery & Development, Other |
References: 2 entries
Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.
High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.
Europe PMC ID: 23169532
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References: 2 entries
Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.
High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.
Add a reference
Inventor Information
Inventors
|
Christoph J. Fahrni |
