Cancer Research Technology
Log in Register
Menu

Fluorescent probe for Copper

Invented by Christoph J. Fahrni

Info

Catalogue Number 153939
Antigen/Gene or Protein Targets Copper I; Cu(I)
Type Fluorescent Probe
Relevance Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. Here, Dr. Farhrni has designed a water-solube fluorescence probe for the detection of aqueous Cu(I). This probe has a high selectivity (57-fold) for Cu(I) compared to other cations such as Cu(II), Hg(II), and Cd(II).
In vitro applications determination of Cu(I) binding affinities of proteins and small-molecule ligands
Solubility water
Research Area Drug Discovery & Development, Other

References

There are 2 reference entries for this reagent.

View All References

References: 2 entries

Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.

High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.

Europe PMC ID: 23169532


Add a reference

References: 2 entries

Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.

High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.


Add a reference

Inventor Information