Anti-STAT1, Polyclonal [ps727]

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References (2)

Inventor Info

Info

Catalogue Number	153528
Applications	IP WB EMSA
Antigen/Gene or Protein Targets	Signal transducer and activator of transcription 1 phosphorylated at residue Serine 727
Synonyms	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
Reactivity	Human
Relevance	In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.
Host	Rabbit
Immunogen	Keyhole limpet hemocyanin (KLH)‐coupled phosphopeptide - sequence DNLLPMpSPEEFDE
Formulation	Serum
Research Area	Cell Signaling & Signal Transduction

There are 2 reference entries for this reagent.

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Kovarik et al. 1998. EMBO J. 17(13):3660-8. PMID: 9649436.

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Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation.

Europe PMC ID: 9649436

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Kovarik et al. 1998. EMBO J. 17(13):3660-8. PMID: 9649436.

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Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation.

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	University of Vienna
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