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Anti-FANCM [CV5.1]

Invented by Dr Stephen West at Francis Crick Institute

Info

Catalogue Number 151822
Applications IF IP WB
Antigen/Gene or Protein Targets Human FANCM (Fanconi anemia, complementation group M)
Synonyms Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250
Reactivity Human
Relevance Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA.

Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
Host Mouse
Immunogen His-tagged denatured FANCM (aa 1507-1679) made in E.coli
Subclass IgG1 kappa
Positive Control 293 cell extract
Notes Suggested Dilutions:

WB - 1:1000, IP - 2-4ug/ml lysate, IF - 1:100

Other species were not tested but there is high sequence conservation.
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

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