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|Applications||IF IP WB|
|Antigen/Gene or Protein Targets||Human FANCM (Fanconi anemia, complementation group M)|
|Synonyms||Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250|
Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA.
Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
|Immunogen||His-tagged denatured FANCM (aa 1507-1679) made in E.coli|
|Positive Control||293 cell extract|
WB - 1:1000, IP - 2-4ug/ml lysate, IF - 1:100
Other species were not tested but there is high sequence conservation.
|Research Area||DNA Damage and Repair, Epigenetics & Nuclear Signalling|
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