Anti-HuD/HuC/HuB [16A11]
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Info
| Catalogue Number | 153503 |
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | HuD |
| Synonyms | ELAV-like protein 4 |
| Reactivity | Human |
| Relevance |
Monoclonal antibody which recognises HuD, HuC and HuB neuronal proteins. Background and Research Application HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. Diseases associated with ELAVL4 include Lambert-Eaton Myasthenic Syndrome and Sensory Peripheral Neuropathy. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. The 16A11 anti-HuD monoclonal is now a classic reagent for the identification of neurons. Antibody 16A11 recognizes the ELAV family members HuC, HuD and Hel-N1 neuronal proteins. It does not recognize HuR, another ELAV family member that is present in all proliferating cells. The antibody has been shown to specifically label neuronal cells in zebrafish, chick, canaries, and humans, and is likely to label neuronal cells in most vertebrate species. |
| Host | Mouse |
| Immunogen | Peptide |
| Immunogen UniProt ID | P26378 |
| Subclass | IgG2b |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Labelling is visible early in development, at about the time that the neurons leave the mitotic cycle. Concentration 1mg/ml as standard |
| Research Area | Developmental Biology, Gene Expression, Neurobiology |
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