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Anti-MAFA, Polyclonal [MAFA]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets MAFA
Reactivity Human and Mouse
Relevance Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell­specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM]  
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Molecular Weight (kDa) 36.8
Research Area Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

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