Anti-c-Met [12.1]
Invented by Dr Julin Wong at University of Dundee
Catalogue Number | 152671 |
Applications | FACS IF IP WB |
Antigen/Gene or Protein Targets | c-Met, cMet |
Reactivity | Human |
Relevance | c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis. |
Host | Mouse |
Immunogen | Bacterially expressed human c-Met alpha chain |
Positive Control | SNU-5, U-87MG and MKN45 cells (negative control: T47D cells) |
Subclass | IgG1 |
Myeloma Used | Sp2/0-Ag14 |
Notes | Epitope: KETKDGFMFL |
Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling |
Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.
Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.
Europe PMC ID: 23859937
Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.
Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.