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Monoclonal Antibodies

Anti-c-Met [17]

Invented by Dr Julin Wong from A*STAR Accelerate Technologies Pte Ltd , David Lane from Karolinska Institutet
Invented at A*STAR Accelerate Technologies Pte Ltd
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FACS analysis on live SNU-5 cells using anti-c-Met [17]
Properties of anti-c-Met [17]
Immunoprecipitation of SNU-5 cell lysates using anti-c-Met [17]. Detection was performed by antibodies SC-10 and AF276.
Immunofluorescence was performed on methanol fixed SNU-5 cells using anti-c-Met [17]
Purification of anti-c-Met [17] from ascites
Western blotting using anti-c-Met [17]
Epitope position on molecule
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Catalogue Number 152665
Applications FACS IF IP WB
Antigen/Gene or Protein Targets c-Met, cMet
Reactivity Human
Relevance c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
Host Mouse
Immunogen Bacterially expressed human c-Met alpha chain
Positive Control SNU-5, U-87MG and MKN45 cells (negative control: T47D cells)
Subclass IgG1 kappa
Myeloma Used Sp2/0-Ag14
Notes Epitope: LVVDTYYDDQ / FRDS - two different epitopes. Note that clone 13 is best for FACS
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

References

There are 2 reference entries for this reagent.

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References: 2 entries

Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.

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Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.

Europe PMC ID: 23859937

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References: 2 entries

Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.

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Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.

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Inventor Information