Cancer Research Technology
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Catalogue Number 152586
Applications ELISA FACS IHC
Antigen/Gene or Protein Targets Mucin1 (MUC1)
Synonyms ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Reactivity Human
Relevance MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
Host Mouse
Immunogen Hydrogen fluoride deglycosylated milk mucin.
Subclass IgG1
Formulation PBS only
Concentration 1mg/ml
Positive Control Ovarian, breast or colon carcinoma, normal intestine or colon
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction
Notes The product of the MUC1 gene is the polymorphic epithelial mucin. SM3 reacts with a core protein epitope defined as PDTRP.
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

*** PLEASE NOTE: Applications stated are those corresponding to original hybridoma ***

References: 2 entries

Original hybridoma first published in Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

Europe PMC ID: 2443241


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References: 2 entries

Original hybridoma first published in Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

Europe PMC ID: 2443241


Add a reference

References: 2 entries

Original hybridoma first published in Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.


Add a reference


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