#152586

Anti-MUC1 [SM3]

Cat. #152586

Anti-MUC1 [SM3]

Cat. #: 152586

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Mucin1 (MUC1)

Class: Recombinant

Application: ELISA ; FACS ; IHC

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Joyce Taylor-Papadimitriou ; Joy Burchell

Institute: Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-MUC1 [SM3]
  • Alternate name: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
  • Clone: rSM3
  • Tool sub type: Primary antibody
  • Class: Recombinant
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC
  • Description: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
  • Immunogen: Hydrogen fluoride deglycosylated milk mucin.
  • Isotype: IgG1
  • Recommended controls: Ovarian, breast or colon carcinoma, normal intestine or colon

Target Details

  • Target: Mucin1 (MUC1)
  • Tissue cell line specificity: Ovarian, breast or colon carcinoma, normal intestine or colon
  • Target background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.

Applications

  • Application: ELISA ; FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS only
  • Storage conditions: -20° C
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-MUC1 [SM3]

References

  • Original hybridoma first published in Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.
  • Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.