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|Antigen/Gene or Protein Targets||c Myc epitope tag|
|Relevance||c-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. Through its role as a transcription factor, c-Myc alters the expression of hundreds of target genes, many of which are themselves oncogenes or tumor suppressors. 9E10 recognises recombinant proteins incorporating a c-Myc epitope tag and detects human c-Myc protein as well as a peptide in random coil configuration not as a helix.|
|Immunogen||Synthetic peptide (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA - 32 aa) corresponding to 408-439 of Human c-Myc conjugated to KLH.|
|Research Area||Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Stem Cell Biology|
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.
Epitope QKLISEEDL in its random, free peptide conformation.
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