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Anti-cMyc [9E10]

Info

Catalogue Number 151067
Applications ChIP ELISA IHC IP WB
Antigen/Gene or Protein Targets c Myc epitope tag
Reactivity Human
Relevance c-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. Through its role as a transcription factor, c-Myc alters the expression of hundreds of target genes, many of which are themselves oncogenes or tumor suppressors. 9E10 recognises recombinant proteins incorporating a c-Myc epitope tag and detects human c-Myc protein as well as a peptide in random coil configuration not as a helix.
Host Mouse
Immunogen Synthetic peptide (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA - 32 aa) corresponding to 408-439 of Human c-Myc conjugated to KLH.
Subclass IgG1 kappa
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Stem Cell Biology

References: 16 entries

Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960.

WB

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Europe PMC ID: 25642960

Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842.

ChIP

The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Europe PMC ID: 24736842

Zhou et al. 2012. J Cell Biol. 196(2):203-11. PMID: 22270916.

IP WB

Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determination.

Europe PMC ID: 22270916

Mendes et al. 2010. J Biol Chem. 285(50):39117-26. PMID: 20937822.

IP WB

Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.

Europe PMC ID: 20937822

Royds et al. 1992. J Pathol. 166(3):225-33. PMID: 1381423.

IHC

Cellular localisation of c-myc product in human colorectal epithelial neoplasia.

Europe PMC ID: 1381423

Spandidos et al. 1987. Anticancer Res. 7(6):1299-304. PMID: 3327455.

IHC

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

Europe PMC ID: 3327455

Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.

IP

Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes.

Europe PMC ID: 3021969

Evan et al. 1985. Mol Cell Biol. 5(12):3610-6. PMID: 3915782.

WB

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Europe PMC ID: 3915782


Add a reference

References: 16 entries

Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960.

WB

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Europe PMC ID: 25642960

Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842.

ChIP

The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Europe PMC ID: 24736842

Zhou et al. 2012. J Cell Biol. 196(2):203-11. PMID: 22270916.

IP WB

Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determination.

Europe PMC ID: 22270916

Mendes et al. 2010. J Biol Chem. 285(50):39117-26. PMID: 20937822.

IP WB

Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.

Europe PMC ID: 20937822

Royds et al. 1992. J Pathol. 166(3):225-33. PMID: 1381423.

IHC

Cellular localisation of c-myc product in human colorectal epithelial neoplasia.

Europe PMC ID: 1381423

Spandidos et al. 1987. Anticancer Res. 7(6):1299-304. PMID: 3327455.

IHC

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

Europe PMC ID: 3327455

Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.

IP

Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes.

Europe PMC ID: 3021969

Evan et al. 1985. Mol Cell Biol. 5(12):3610-6. PMID: 3915782.

WB

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Europe PMC ID: 3915782


Add a reference

References: 16 entries

Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960.

WB

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842.

ChIP

The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Zhou et al. 2012. J Cell Biol. 196(2):203-11. PMID: 22270916.

IP WB

Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determination.

Mendes et al. 2010. J Biol Chem. 285(50):39117-26. PMID: 20937822.

IP WB

Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.

Royds et al. 1992. J Pathol. 166(3):225-33. PMID: 1381423.

IHC

Cellular localisation of c-myc product in human colorectal epithelial neoplasia.

Spandidos et al. 1987. Anticancer Res. 7(6):1299-304. PMID: 3327455.

IHC

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.

IP

Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes.

Evan et al. 1985. Mol Cell Biol. 5(12):3610-6. PMID: 3915782.

WB

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.


Add a reference


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