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|Antigen/Gene or Protein Targets||Surface protein Pfs48/45|
|Relevance||Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is expressed by male and female gametes of Plasmodium falciparum and PFS48/45 antibodies prevent zygote development and transmission. Pfs 48/45 is therefore a good target antigen of malaria transmission blocking antibodies.|
|Immunogen||Gametocytes of the 7G8 isolate (Plasmodium falciparum isolated from a 12 year old male from Manaus, Brazil on 12th March 1980 by Dr. K.M. McNeil)|
UK Biosafety level: 1
Recognises an epitope of P. falciparum Pfs48/45. Non-inhibitory in mosquito membrane feeding assays.
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