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Anti-NY-ESO-1 [E978]

Info

Applications ELISA
Antigen/Gene or Protein Targets NY-ESO-1
Relevance Cancer/testis (CT) antigens are the protein products of genes that are activated in a wide variety of tumors and can elicit autologous cellular and humoral immune responses. Their normal expression is restricted to male germ cells in the testis and they are not expressed in adult somatic tissues. Therefore, CT antigens are promising candidates for cancer immunotherapy. Approximately 20 CT antigens or antigen families have been identified to date. NY-ESO-1 is a CT protein to which cell-mediated immune response has been demonstrated. The protein is expressed in normal testis and to a much lower extent in placenta, ovary and uterus. However, it is mainly expressed in many different cancers. The expression of genes encoding CT antigens has been found in sporadic medullary thyroid carcinoma, breast cancer especially in benign lesions and in multiple myeloma. Due to its wide expression in different cancers, NY-ESO-1 protein was used as a vaccine in cancer patients.
Host Mouse
Research Area Cancer, Cell Type or Organelle Marker

References: 1 entry

Stockert et al. 1998. J Exp Med. 187(8):1349-54. PMID: 9547346.


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References: 1 entry

Stockert et al. 1998. J Exp Med. 187(8):1349-54. PMID: 9547346.


Add a reference

References: 1 entry

Stockert et al. 1998. J Exp Med. 187(8):1349-54. PMID: 9547346.


Add a reference


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