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Anti-HDAC2 [3F3]

Invented by Egon Ogris at Medical University Of Vienna

Info

Applications IP WB
Antigen/Gene or Protein Targets HDAC2
Reactivity Bovine, Hamster, Human, Mouse and Rat
Relevance Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly conserved from yeast to human.
Host Mouse
Immunogen Synthetic peptide corresponding to N-terminal region of human HDAC2
Subclass IgG1
Molecular Weight (kDa) 55
Research Area Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Stem Cell Biology

References: 4 entries

Dovey et al. 2010. Proc Natl Acad Sci U S A. 107(18):8242-7. PMID: 20404188.

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Europe PMC ID: 20404188

Rashid et al. 2009. J Biol Chem. 284(27):18115-28. PMID: 19433865.

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

Europe PMC ID: 19433865


Add a reference

References: 4 entries

Dovey et al. 2010. Proc Natl Acad Sci U S A. 107(18):8242-7. PMID: 20404188.

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Europe PMC ID: 20404188

Rashid et al. 2009. J Biol Chem. 284(27):18115-28. PMID: 19433865.

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

Europe PMC ID: 19433865


Add a reference

References: 4 entries

Dovey et al. 2010. Proc Natl Acad Sci U S A. 107(18):8242-7. PMID: 20404188.

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Rashid et al. 2009. J Biol Chem. 284(27):18115-28. PMID: 19433865.

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.


Add a reference


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