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MEF Trex1 KO Cell Line


Catalogue Number 151558
Antigen/Gene or Protein Targets TREX1
Host Mouse
Tissue Embryo
Disease Keywords Recapitulates cellular phenotype of Trex1-deficient Aicardi-Goutieres syndrome
Model Knock-Out
Relevance The Trex1 KO MEF cell line is a spontaneously transformed mouse embryonic fibroblast (MEF) cell line. It allows the study of novel interconnections between DNA replication, DNA damage checkpoint signalling and antiviral-like autoimmune responses
Production Details MEF from Trex1-/- knockout mouse
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling, Immunology
Growth/Phenotype Keywords Defective G1/S transition, increased cell doubling time; chronic ATM-dependent checkpoint activation even in the absence of exogenous stress; persistant ssDNA polynucleotide species generated in S phase that accumulates in the cytoplasm.
Notes Spontaneously transformed clone derived following repeated passaging in culture by standard techniques of primary MEFs from Trex1-/- knockout mouse
Cellosaurus ID CVCL_5A06

References: 2 entries

Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.

Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.

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