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Trex1 -/- Mouse


Catalogue Number 151578
Antigen/Gene or Protein Targets TREX1
Disease Keywords Antiviral-like autoimmunity; autoinflammatory disease; Aicardi-Goutieres syndrome
Relevance Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse
Production Details Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.
Conditional No
Growth/Phenotype Keywords Autoimmunity manifested as inflammatory myocarditis / reduced lifespan
Mouse Genetic Background/Cross History 129/C57BL6
Zygosity Homozygous
Research Area Drug Discovery & Development, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology

References: 2 entries

Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.

Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.

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