MEF Trex1 KO Cell Line
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
Trex1 -/- Mouse
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151578 |
| Antigen/Gene or Protein Targets | TREX1 |
| Disease Keywords | Antiviral-like autoimmunity; autoinflammatory disease; Aicardi-Goutieres syndrome |
| Relevance | Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse |
| Production Details | Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal. |
| Conditional | No |
| Growth/Phenotype Keywords | Autoimmunity manifested as inflammatory myocarditis / reduced lifespan |
| Mouse Genetic Background/Cross History | 129/C57BL6 |
| Zygosity | Homozygous |
| Research Area | Drug Discovery & Development, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology |
References: 4 entries
Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Europe PMC ID: 18045533
Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
Europe PMC ID: 15254239
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References: 4 entries
Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
Add a reference
