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Anti-Phospho RNA polII (Ser5) [CTD 8A7]

Invented by Dr Jesper Svejstrup at Francis Crick Institute

Info

Catalogue Number 151243
Applications ELISA FACS IF WB
Antigen/Gene or Protein Targets RNA Polymerase II (Phosphorylated)
Reactivity Human and Saccharomyces cerevisiae
Relevance RNAPII is an essential component of the RNAP II transcription elongation complex. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the C-terminal repeat (YSPTSPS) domain of the largest subunit of RNAPII.
Host Mouse
Immunogen Peptide: 10 repeats of synthetic peptide YSPTSPS using chemically sythesized phospho-Ser5.
Subclass IgM
Positive Control S. cerevisiae and HeLa cells
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Epigenetics & Nuclear Signalling

References: 8 entries

Benferhat et al. 2012. J Virol. 86(20):11333-44. PMID: 22896612.

IF

Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.

Europe PMC ID: 22896612

Alm-Kristiansen et al. 2011. Mol Cancer. 10:21. PMID: 21338522.

IF

PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.

Europe PMC ID: 21338522

Aune et al. 2008. Clin Cancer Res. 14(20):6449-55. PMID: 18927284.

WB

Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

Europe PMC ID: 18927284

Otero et al. 1999. Mol Cell. 3(1):109-18. PMID: 10024884.

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Europe PMC ID: 10024884


Add a reference

References: 8 entries

Benferhat et al. 2012. J Virol. 86(20):11333-44. PMID: 22896612.

IF

Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.

Europe PMC ID: 22896612

Alm-Kristiansen et al. 2011. Mol Cancer. 10:21. PMID: 21338522.

IF

PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.

Europe PMC ID: 21338522

Aune et al. 2008. Clin Cancer Res. 14(20):6449-55. PMID: 18927284.

WB

Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

Europe PMC ID: 18927284

Otero et al. 1999. Mol Cell. 3(1):109-18. PMID: 10024884.

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Europe PMC ID: 10024884


Add a reference

References: 8 entries

Benferhat et al. 2012. J Virol. 86(20):11333-44. PMID: 22896612.

IF

Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.

Alm-Kristiansen et al. 2011. Mol Cancer. 10:21. PMID: 21338522.

IF

PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.

Aune et al. 2008. Clin Cancer Res. 14(20):6449-55. PMID: 18927284.

WB

Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

Otero et al. 1999. Mol Cell. 3(1):109-18. PMID: 10024884.

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.


Add a reference


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