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HEK293-ratCEACAM1-Fc cell line

Invented at LeukoCom

Info

Catalogue Number 160697
Antigen/Gene or Protein Targets rat CEACAM1
Parental Line HEK293
Synonyms Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a
Host Human
Tissue Kidney
Model Transgenic
Relevance CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response
Production Details Overexpression of rat CEACAM1-Fc Chimera Protein
Conditional No
Research Area Adhesion, Cancer
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions DMEM + 10% FBS

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