Cancer Research Technology
Log in Register
Menu

HEK293-CEACAM1-dN-Fc (without N domain) cell line

Invented at LeukoCom

Info

Catalogue Number 160686
Antigen/Gene or Protein Targets CEACAM1
Parental Line HEK293
Synonyms Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a
Host Human
Tissue Kidney
Model Transgenic
Relevance CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response
Production Details Overexpression of human CEACAM1 (lacking the N domain)-Fc Chimera Protein
Conditional No
Research Area Adhesion, Cancer, Immunology
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions DMEM + 10% FBS

References

There are 0 reference entries for this reagent.

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor