Anti-HIP1r [1E1] monoclonal antibody
Invented at University Of Michigan
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- References (1)
- Inventor Info
Info
| Catalogue Number | 160649 |
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | HIP1r |
| Synonyms | Huntingtin-interacting protein 1-related clone 1E1 |
| Reactivity | N/A |
| Relevance |
Hybridoma cell line producing the monoclonal antibody, Huntingtin-interacting protein 1-related clone 1E1 (HIP1r [1E1]), the only known mammalian relative of HIP1. HIP1 interacts with huntingtin, the protein whose gene is mutated in Huntington's disease and has been shown to transform fibroblasts via undefined mechanisms. Studies by Hyun and colleagues (PMID: 14732715) have shown that HIP1 and HIP1R share a functional homology via binding to 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases that may contribute to their overall ability to alter cell growth and survival. The inhibition of HIP1 and HIP1R activity have been shown to interfere with the function of multiple growth factor receptors in tumors. HIP1 and HIP1r have also been shown to stabilize growth factor receptor levels via altered intracellular trafficking and have been suggested to play a critical role in the regulation of endocytosis via association with clathrin coats (PMID: 11604514). |
| Host | Mouse |
| Immunogen | pGEX-HIP1r/TH |
| Notes | Unconjugated |
| Research Area | Developmental Biology, Neurobiology |
