Anti-HIP1 [1A1] monoclonal antibody
Invented at University Of Michigan
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 160648 |
| Applications | WB |
| Antigen/Gene or Protein Targets | HIP1 |
| Synonyms | Huntingtin-interacting protein 1 clone 1A1 |
| Reactivity | N/A |
| Relevance |
Hybridoma cell line producing the murine monoclonal antibody Huntingtin-interacting protein 1 clone 1A1 (HIP1 [1A1]). HIP1 interacts with huntingtin, the protein whose gene is mutated in Huntington's disease and has been shown to transform fibroblasts via undefined mechanisms. Studies by Hyun and colleagues (PMID: 14732715) have shown that HIP1 and HIP1R share a functional homology via binding to 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases that may contribute to their overall ability to alter cell growth and survival. The inhibition of HIP1 and HIP1R activity have been shown to interfere with the function of multiple growth factor receptors in tumors. HIP1 and HIP1r have also been shown to stabilize growth factor receptor levels via altered intracellular trafficking and have been suggested to play a critical role in the regulation of endocytosis via association with clathrin coats (PMID: 11604514). |
| Host | Mouse |
| Immunogen | Purified 3'HIP1 protein |
| Notes | Unconjugated |
| Research Area | Developmental Biology, Neurobiology |
