Creatine Kinase B (CK-BYK) [2E10] Monoclonal Antibody
Invented by Bé Wieringa
Invented at Radboud UMC
- Datasheet
- References (3)
- Inventor Info
Info
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| Catalogue Number | 160393 |
| Applications | EM IHC IF WB |
| Antigen/Gene or Protein Targets | Brain-type creatine kinase |
| Synonyms | CKBB, creatine phosphokinase, phosphocreatine kinase |
| Reactivity | Human, Mouse, Rat and Rabbit |
| Relevance | Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes with a high and sudden energy demand. We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling. |
| Host | Mouse |
| Immunogen | A synthetic 17-mer peptide corresponding to a unique sequence in the amino-terminal region of human creatine kinase B |
| Subclass | IgG2b |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Notes | This is a highly B-subunit-specific monoclonal antibody for creatine kinase. |
| Research Area | Cell Structure and Motility, Metabolism, Neurobiology |
References: 3 entries
Venter et al. 2015. Eur J Cell Biol. 94(2):114-27. PMID: 25538032.
EM WB
Sistermans et al. 1995. Cell Tissue Res. 280(2):435-46. PMID: 7781040.
EM IF WB
de Kok et al. 1995. Mol Cell Biochem. 143(1):59-65. PMID: 7776959.
WB
Add a reference
References: 3 entries
Venter et al. 2015. Eur J Cell Biol. 94(2):114-27. PMID: 25538032.
EM WB
Sistermans et al. 1995. Cell Tissue Res. 280(2):435-46. PMID: 7781040.
EM IF WB
de Kok et al. 1995. Mol Cell Biochem. 143(1):59-65. PMID: 7776959.
WB
Add a reference
