Anti-ALCAM AZN-L51 (IgG1) [AZNL51] monoclonal antibody
Invented by Carl Figdor at Radboud UMC
Catalogue Number | 159675 |
Applications | FACS IP WB |
Antigen/Gene or Protein Targets | Activated leukocyte cell adhesion molecule |
Synonyms | CD166 antigen, MEMD |
Reactivity | Human |
Relevance | ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression. |
Host | Mouse |
Immunogen | K562-ALCAM |
Immunogen UniProt ID | Q13740 |
Subclass | IgG2a |
Strain | Balb/c |
Notes | AZN50 is able to block the activity of ALCAM, both in terms of cell adhesion and interaction with CD6. |
Research Area | Adhesion, Cancer, Immunology |