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Anti-ALCAM AZN-L50 (IgG2A) [AZNL50] monoclonal antibody

Invented by Carl G. Figdor
Invented at Radboud UMC

Info

Catalogue Number 159675
Applications FACS IP WB
Antigen/Gene or Protein Targets Activated leukocyte cell adhesion molecule
Synonyms CD166 antigen, MEMD
Reactivity Human
Relevance ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression.
Host Mouse
Immunogen K562-ALCAM
Immunogen UniProt ID Q13740
Subclass IgG2a
Strain Balb/c
Notes AZN50 is able to block the activity of ALCAM, both in terms of cell adhesion and interaction with CD6.
Research Area Adhesion, Cancer, Immunology

References

There are 1 reference entries for this reagent.

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References: 1 entry

Te Riet et al. 2007. J Cell Sci. 120(Pt 22):3965-76. PMID: 17971418.

FACS IP WB


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References: 1 entry

Te Riet et al. 2007. J Cell Sci. 120(Pt 22):3965-76. PMID: 17971418.

FACS IP WB


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Inventor Information

Inventors

Carl G. Figdor

Carl G. Figdor

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