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Catalogue Number
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158407 |
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Applications
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IHC
IP
WB
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Antigen/Gene or Protein Targets
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Calcium Sensing Receptor (CaSR)
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Synonyms
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CaSR, CaR
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Reactivity
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Human, Mouse, Rat and Rabbit
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Relevance
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Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.
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Host
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Mouse
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Immunogen
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Synthetic peptide corresponding to amino acids 15-29 in the extracellular amino terminus of human CaSR
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Subclass
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IgG1 kappa
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Notes
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Bands are seen at 140 kDa and 125 kDa on WB
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Research Area
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Cell Signaling & Signal Transduction, Cardiovascular
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