Anti-calcium-sensing receptor [HL1499]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-calcium-sensing receptor [HL1499]
• Alternate name: CaSR, CaR
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human ; Mouse ; Rat ; Rabbit
• Host: Mouse
• Application: WB ; IHC ; IP
• Description: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.
• Immunogen: Synthetic peptide corresponding to amino acids 15-29 in the extracellular amino terminus of human CaSR
• Isotype: IgG1 kappa

Target Details

• Target: Calcium Sensing Receptor (CaSR)
• Target background: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.

Applications

• Application: WB ; IHC ; IP

Handling

• Format: Liquid
• Unit size: 100 ug
• Storage conditions: -20° C
• Shipping conditions: Shipping at 4° C

References

• Awata et al. 2001. J Biol Chem. 276(37):34871-9. PMID: 11390379.