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p110beta PI3K-DEL21/22 (B6)
RECENTLY UPDATED

Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research , The University of Edinburgh

Info

Catalogue Number 158393
Antigen/Gene or Protein Targets PIK3CB
Model Knock-Out
Production Details Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
Mouse Genetic Background/Cross History Backcrossed onto C57B6/J for more than 10 generations.
Research Area Cancer
Notes Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.

Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.


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References: 2 entries

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.

Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.


Add a reference