p110beta PI3K-DEL21/22 (B6)
Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research , The University of Edinburgh
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 158393 |
| Antigen/Gene or Protein Targets | PIK3CB |
| Model | Knock-Out |
| Production Details | Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background. |
| Mouse Genetic Background/Cross History | Backcrossed onto C57B6/J for more than 10 generations. |
| Research Area | Cancer |
| Notes | Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous. |
References: 2 entries
Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.
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References: 2 entries
Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.
Add a reference
Inventor Information
Inventors
|
Bart Vanhaesebroeck |
