#158393

p110beta PI3K-DEL21/22 (B6)

Cat. #158393

p110beta PI3K-DEL21/22 (B6)

Cat. #: 158393

Sub-type: Mouse

Availability: 6-8 weeks

Model: Knock-Out

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Bart Vanhaesebroeck

Institute: Ludwig Institute for Cancer Research ; The University of Edinburgh

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: p110beta PI3K-DEL21/22 (B6)
  • Tool sub type: Mouse
  • Model: Knock-Out
  • Genetic background: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
  • Phenotype: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.
  • Production details: Mice in which exons 21 and 22 from PIK3CB/p110beta are constitutively deleted by crossing to a Cre-deleter strain - backcrossed onto B6 background.
  • Additional notes: Homozygous p110bD21-22/D21-22 mice can be obtained. Heterozygous mice show reduced phenotypes of homozygous.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: PIK3CB

References

  • Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
  • Guillermet-Guibert et al. 2008. Proc Natl Acad Sci U S A. 105(24):8292-7. PMID: 18544649.