Anti-Irisin [VAB11 P2C12*C11] monoclonal antibody
Invented by Abdo Alnabulsi
Invented at Vertebrate Antibodies Limited
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Info
| Catalogue Number | 158034 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Irisin |
| Reactivity | Human |
| Relevance |
Irisin belongs to the class of adipomyokines since it acts both in adipose and muscle tissue (adipokine and myokine) and is a thermogenic protein that promotes energy expenditure by white adipose tissue (WAT) browning. Irisin is secreted from muscles in response to exercise and may mediate some beneficial effects of exercise in humans, such as weight loss and thermoregulation. Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). FNDC5 converts to irisin after exercise. Irisin dissipates energy as heat and for this reason its discovery has generated a flurry of research aimed at understanding the mechanisms of energy metabolism. Irisin is expected to be a potential therapeutic agent for the treatment of obesity and its related conditions. This tool is significant as the peptide immunogen used to generate antibodies is conserved across all vertebrates. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved across all vertebrates. |
| Positive Control | ELISA: peptide immunogen, recombinant protein WB: recombinant protein IHC: formalin-fixed, paraffin-embedded multi-tissue microarray |
| Subclass | IgG |
| Molecular Weight (kDa) | 12 |
| Strain | Balb/c |
| Notes |
Applications and Recommended Usage Conditions: - WB recommended to be used Neat - IHC recommended to be used Neat, antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0. - ELISA recommended to be used Neat Fusion Partner is Ag 8563 Unpurified; supplied as hybridoma supernatant |
| Research Area | Cell Type or Organelle Marker, Immunology |
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Inventor Information
Inventors
|
Abdo Alnabulsi |
